Three weeks after starting sertraline, an 83-year-old woman has new confusion and unsteadiness. She is clinically euvolemic. Labs: serum sodium 124 mEq/L, serum osmolality 258 mOsm/kg, urine osmolality 480 mOsm/kg, urine sodium 52 mEq/L, normal TSH and cortisol. Which diagnosis best fits?
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Answer: C
Hypovolemic hyponatremia from poor fluid intake: Hypovolemia usually gives a low urine sodium (under 20 to 30 mEq/L) and clinical volume depletion; she is euvolemic with a high urine sodium.
Primary polydipsia with excessive water intake: With primary polydipsia the kidneys excrete very dilute urine (osmolality under 100 mOsm/kg), not concentrated urine.
SIADH associated with the SSRI antidepressant: Correct. Low serum osmolality with inappropriately concentrated urine and high urine sodium in a euvolemic patient, with thyroid and adrenal causes excluded, fits SIADH. Older adults on SSRIs are at particular risk.
Pseudohyponatremia from high lipids or protein: Pseudohyponatremia has a normal measured serum osmolality; hers is low, so the hyponatremia is real (hypotonic).
Hypotonic, euvolemic hyponatremia with urine osm >100 and urine Na >30, after excluding hypothyroidism and adrenal insufficiency = SIADH; SSRIs are a common cause in older adults.