A severely malnourished patient (BMI 15) started on enteral feedings 2 days ago now has new weakness, confusion, peripheral edema and shortness of breath. Which laboratory result is most consistent with the likely complication?
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Answer: C
Serum potassium 5.8 mEq/L: Refeeding syndrome drives potassium into cells, causing hypokalemia, not hyperkalemia.
Serum calcium 11.2 mg/dL: Hypercalcemia is not a feature of refeeding syndrome.
Serum phosphorus 1.2 mg/dL: Correct. Refeeding syndrome happens when nutrition restarts after starvation: insulin release shifts phosphorus, potassium and magnesium into cells. Severe hypophosphatemia causes weakness, respiratory failure, confusion and heart failure. Prevention: start feeds slowly, give thiamine, and monitor and replace electrolytes.
Serum magnesium 3.1 mg/dL: Refeeding causes hypomagnesemia, not elevated magnesium.
Refeeding syndrome (first 72 hours of feeding in a malnourished patient): low phosphorus is the hallmark, with low potassium and magnesium, fluid retention and thiamine deficiency. Start low, go slow.