A pressure injury has shown no reduction in size for eight weeks despite offloading. Which biochemical feature most typically characterizes the fluid of a chronic, stalled wound compared with an acute wound?
Show answer & explanation
Answer: B
Low protease levels that leave the extracellular matrix intact: Incorrect. Chronic wounds have high, not low, protease activity.
High matrix metalloproteinase levels that degrade growth factors: Correct. Chronic wounds are often stuck in prolonged inflammation, with elevated MMPs that break down growth factors, receptors and new matrix.
High growth factor levels that speed up epithelial migration: Incorrect. Growth factors are reduced or degraded in chronic wound fluid.
Low bacterial burden that prevents any inflammatory response: Incorrect. Chronic wounds commonly carry biofilm and increased bioburden that sustain inflammation.
Chronic wounds: prolonged inflammation, excess proteases (MMPs), senescent cells, biofilm and depleted growth factors; wound bed preparation aims to correct this.