A family asks a psychologist what the Treatment for Adolescents With Depression Study (TADS) found after 12 weeks of acute treatment. Which summary is accurate?
Show answer & explanation
Answer: C
CBT alone and fluoxetine alone were equally effective, and both were superior to placebo.: At 12 weeks fluoxetine alone outperformed CBT alone, and CBT alone did not separate from placebo.
CBT alone matched the combination and was the preferred first treatment.: CBT alone had the lowest active response rate at 12 weeks; it was not equal to the combination.
Combined treatment responded best, and CBT alone did not differ from placebo.: Correct. At 12 weeks response rates were about 71% for fluoxetine plus CBT, 61% for fluoxetine, 43% for CBT and 35% for placebo; CBT alone was not significantly better than placebo (KN3).
Fluoxetine alone had the highest response rate and was significantly better than the combination.: Fluoxetine alone was effective but below the combination; the combination produced the best acute outcome.
TADS acute phase: combined fluoxetine plus CBT was best, fluoxetine alone next, and CBT alone was not superior to placebo at 12 weeks.