A patient with HIV infection has painless, white, corrugated (vertically ridged) patches on the lateral borders of the tongue that cannot be wiped off. Which lesion is most likely?
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Answer: B
Pseudomembranous candidiasis: Pseudomembranous candidiasis forms white plaques that can be wiped off, leaving a red base.
Oral hairy leukoplakia: Correct. Hairy leukoplakia is an Epstein-Barr virus lesion of the lateral tongue that is corrugated and cannot be wiped off.
Geographic tongue: Geographic tongue shows red, depapillated patches with white borders that move over time, mainly on the dorsum.
Linea alba: Linea alba is a white line on the buccal mucosa along the occlusal plane, not on the lateral tongue.
Oral hairy leukoplakia: EBV-related, lateral tongue, corrugated, does not wipe off; a marker of immunosuppression such as HIV.