A 28-year-old man admitted for acute psychosis received several intramuscular doses of haloperidol over 2 days. He now has a temperature of 40.1°C, labile blood pressure (168/100 mm Hg), heart rate 124/min, diaphoresis, confusion and generalized lead-pipe rigidity. CK is 18,000 U/L. Reflexes are normal and there is no clonus. What is the most appropriate initial action?
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Answer: D
Give cyproheptadine and continue the antipsychotic at a lower dose: Cyproheptadine treats serotonin syndrome, which features clonus and hyperreflexia. Continuing any dopamine blocker would worsen NMS.
Add benztropine and recheck the CK level in 1 week: Anticholinergics treat dystonia and parkinsonism, not NMS, and can impair heat loss. A week's delay ignores a life-threatening emergency.
Switch to an intramuscular second-generation antipsychotic: Second-generation antipsychotics also block D2 receptors and can cause or prolong NMS; all antipsychotics should be stopped.
Stop the haloperidol and begin cooling, IV fluids and close monitoring: Correct. Fever, rigidity, autonomic instability, altered mental status and a high CK after a D2 blocker indicate NMS. Stop the drug and give intensive supportive care; dantrolene or bromocriptine may be added.
NMS = dopamine blockade + hyperthermia + lead-pipe rigidity + autonomic instability + high CK, developing over days; stop the antipsychotic and support. Clonus and hyperreflexia point to serotonin syndrome instead.