A patient scheduled for a diagnostic PSG takes a selective serotonin reuptake inhibitor (SSRI) antidepressant every morning. Which effect on the study is most likely?
Show answer & explanation
Answer: C
Increased REM sleep with a shortened REM latency: This pattern is typical of SSRI withdrawal (REM rebound), not ongoing SSRI use.
Marked increase in N3 slow-wave sleep amount: SSRIs do not substantially increase slow-wave sleep.
REM suppression with a prolonged REM latency: Correct. SSRIs suppress REM and lengthen REM latency; they can also cause eye movements in NREM and REM sleep without atonia.
Abundant sleep spindles and excess beta activity: Increased spindles and beta activity are characteristic of benzodiazepines and related hypnotics.
Antidepressants (SSRIs, SNRIs, TCAs) suppress REM; abrupt withdrawal causes REM rebound. Benzodiazepines increase spindles/beta and reduce N3.